Bothd- andl-Glucose Polyphosphates Mimicd-myo-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P3Receptor

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myo-inositol 1,4,6-trisphosphorothioate and myo-inositol 1,3, 6-trisphosphorothioate: partial agonists with very low intrinsic activity at the platelet myo-inositol 1,4,5-trisphosphate receptor.

Racemic mixtures and enantiomerically pure D-isomers of both myo-inositol 1,3,6-trisphosphorothioate [Ins(1,3,6)PS(3)] and myo-inositol 1,4,6-trisphosphorothioate [Ins(1,4,6)PS(3)], prepared by total synthesis, were examined in Ca(2+) flux and binding assays. Both D-Ins(1,3,6)PS(3) and D-Ins(1,4,6)PS(3) were shown to be low intrinsic activity partial agonists at the platelet myo-inositol 1,4, 5...

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Dephosphorylation of myo - inositol 1 , 4 , 5 - trisphosphate and myo - inositol 1 , 3 , 4 - trisphosphate Stephen

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Synthetic partial agonists reveal key steps in IP3 receptor activation

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ژورنال

عنوان ژورنال: Journal of Medicinal Chemistry

سال: 2020

ISSN: 0022-2623,1520-4804

DOI: 10.1021/acs.jmedchem.0c00215